estrogen priming protocol success over 40 combivent

No BCP - started my period, did cycle day 2 testing FSH was good (I had high a FSH of 15 so EPP helped that) then started meds. Estrogen Priming is completely different, so therefore without birth control pill.I would ask your doctor, but I guess you just do nothing while preparing for the cycle. This is standard practice when ordering from Ukraine, according to customers wh. However, when it comes to specific IVF populations, its clear that certain strategies and doses are better than others. Both were immature. Are you sure you want to block this member? Candice maybe11 129 Dec 08, 2009 #3 Hi, 14 retrieved, 9 mature, 5 fertilized normally, 2 grew to the 2-cell stage then arrested, 3 did not grow beyond one cell. I did have a decent response on the MDL and 100% fertilization with two good 5 day blasts. Northwestern Medicine. So it's a low dose of Lupron, but not necessarily low doses of stims overall. - Longdom This drug works indirectly by prompting the brain to produce more gonadotropin to signal the ovaries to grow follicles -- so it's not directly stimulating the ovary. I am only 28 with normal amh/fsh levels so we were pretty shocked and upset when we only had a couple embryos on day 3 and then nothing to freeze. Sadly, both my hatching blasts were abnormal. It was my best in terms of numbers and success. When do you start your next cycle? Privacy Policy - IVF#5 July 2010 - will be using estrogen priming Estrogen Priming Protocol- EPP Experiences. I asked for iv antibiotics instead of the zpack because I've never taken it before and was worried about how I'd feel from it. I used two patches a dayandchanged the patches every third day. Many customers have had positive experiences ordering from them, and their customer service has been praised for keeping buyers updated on order status. me: 37 Any 43+ Have Successful IVF with Own Egg? Time is of the essence and whatever information we have, we are happy to share to help you! Natural cycle is no meds to stim so u get 1 egg at best. I had success with EPP after failing with other protocols. They said that they look at FSH less now as they find it too unreliable. However, that information will still be included in details such as numbers of replies. These include estrogen, FSH, LH and inhibin amongst many others. I hope your's goes lots better than mine! That data comes from an analysis of over 700,000 IVF cycles run by well-respected investigators at Stanford. Here's what you need to know about the project. I did a phone consult with Sher and he suggested the conversion protocol to me as well. As you can see in our summary below, there are multiple drugs that can perform these two functions the one thats chosen dictates the protocol strategy. However, the data doesnt bare that out. Several functions may not work. The dose of gonadotropin is typically measured in International Units Per Day and ranges from 0 - 900 with most IVF patients receiving 250 - 450 IUs per day. I don't know why they didn't take, but I still think it is a good one to try. This hormone is injected by the patient and directly instigates the ovaries to grow more follicles. Mar 15, 2011 #2. High FSH. My next cycle will also be EPP. This is caused by insufficient potassium reaching the fruit due to environmental factors such as high air/soil temperatures and overcast skies or heavy fruit load on plants with lower organic matter content in their soils. Fingers crossed that your period waits for the right day. President, ASRM Hi there. FSH 7.7 ( done 1 year ago ) First round , on bcp for 2.5 weeks. These drugs signal to the brain not to instigate ovulation. I dont know as much about micro flare. I'm starting with this IUI and then will see how I respond and move forward from there. It was day 3 of my period. you are not supposed to TTC on the cycle you will be doing the EPP because of the ganirelix. Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. AMH 28. Hi there. It's possible to pay with credit card or Western Union, but PayPal isn't an option. Regular menstrual cycles between 21 and 40 days Presence of both ovaries Meets criteria for DOR by the recent ASRM/ACOG Committee Opinion antimllerian hormone (AMH) value less than 1 ng/mL antral follicle count less than 5-7 and follicle-stimulating hormone (FSH) greater than 10 IU/L or The deadline for sending in seeds was October 15th, but there are still plenty of ways to get involved. I then did 450 gonal-F and 150 menopur for 12 or 13 days, using ganirelix as well. (This was to work with their schedule, because they are closed on the weekends.) But not all patients respond equally to ovarian stimulation using these hormones. New doctor recommended EPP to promote more even follicle growth. This drugs known as the trigger shot. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Back to home page. As you may recall in the Revelli and Yousef studies, 150 IUs per day of gonadotropin were used, which is well higher than most things marketed as mini-stimulation approaches, and any natural (no gonadotropin) approach. How did it go with the EPP? 1st IVF/ICSI age 41 : Gonal F 300; 3 eggs; 2 fertilised; transfer day 5; BFN 13 days stim. This will be my first IVF round and I w, Hi All, November 8 - we're having twins:) Wow!!! Its effective, but expensive, and raises the risk of OHSS. And I think EPP is the standard at CCRM as well for DOR ladies. Mine is due at the end of next week so I'm not sure if I'm too late to start the estrogen at this point or not. The dr decided to put a halt to the process for that month. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Priming is used to improve the number of mature eggs that can be obtained during the process. we did another one without BCPs and that also failed. (Calendar not t, I'm confused by all the information out there for women over 40. Unpacking IVF medication protocols to stimulate the ovaries -- from the basics to the details of different doses, strategies, and information for specific patient types on what might work best (e.g. Was wondering since your AMH was good and FSH, why did they recommend the Estrogen priming protocol for you? Sign up now for your monthly dose of fertility info, experiences, and insight. Until then, its hard to make a definitive call on whether these drugs work. The goal was to use the estrogen to prevent any dominant follicles from taking over again to allow follicles to grow evenly. Anyone with very low AMH do the estrogen priming and have a good response? As a result, a woman needs to start the process with many eggs. A gonadotropin-releasing antagonist hormone (GnRH-ant) is used to stop the ovaries from releasing the matured eggs and allows time for additional maturation until eggs are retrieved for fertilization. Estrogen Priming is completely different, so therefore without birth control pill. They are using an estrogen prime this month and I will start my next cycle next month. IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. Please whitelist our site to get all the best deals and offers from our partners. Hi. poor responders or women with PCOS). Hey Michelle, I haven't forgotten about you. From what I've seen on the boards, ladies get a higher number and higher quality. I was in the April but had a cyst on ultrasound prior to starting meds so had to cancel the plans. I am on my 4th now. On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. IVF Compared To Other Fertility Treatments, The Steps and Decisions In The IVF Process, Pregnancy Testing, Early Pregnancy and Delivery, The Impact of Donor Eggs, Donor Sperm or A Gestational Surrogate, The Impact of A Patients Condition or Diagnosis, Fertilization With Conventional Insemination vs. ICSI, Which Patients Benefit From Which Approach, Growing Embryos To Cleavage or Blastocyst Stage, Exceptions Where Cleavage Stage Makes Sense, PGT-A and PGS Genetic Screening of Embryos, Benefits of PGT-A (or PGS) Genetic Testing, The Negatives of PGT-A (or PGS) Genetic Screening. Are they all the same thing? Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. Froze 3. Initial was 12. IVF#2 started sept 19th Only 2 drugs during stim and finally got one good pgs tested embryo!!! To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. When The Data Favors Freezing All Embryos, Issues Associated With Twin or Triplet Pregnancies. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. In my case, antral follicle count is very poor, but RE decides to proceed. I hav, My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. It's that time of year again when gardeners all over the world are planning what to grow in their gardens. Was wonderin, I just finished my 3rd failed IVF cycle using EPP. We are going to bump up my gonal f too. It's not the same for everyone over 40. Any success stories for low responders of Estrogen Priming cycle? I started my estrace this morning and feel a little icky so far. maternal age" i.e. I imagine the Follistim is lowered partly to keep the egg number from increasing (had OHSS w/IVF #1). Best of luck to you. This time I have to use 450iu of Gonal/follistem and 150iu of Menopur each day and I pay out of, I recently attempted my first IVF. So.. You can see my sig. A flare cycle may involve OCP or estrogen-only pretreatment, but the key is that a GnRH agonist (Lupron, Suprefact, or Synarel) will be started at exactly the same time as the stimulating medication. This clinic only biopsies hatching blasts. FET April 2009 - cancelled, embryos did not survive thaw 225 Gonal f and 225 menopur for 4 days then menopur only (450) for the rest of my stims. That could be bogus, but it makes sense, right? Yes, I did antagonist for IVF 1, 2 and 3. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. These drugs perform the opposite duty of suppression. In that time a womans hormonal balance has been restored and so IVF cycles using a frozen transfer are more likely to work. Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? Hey ladies, I am about to start my second IVF cycle and this time instead of priming with birth control I am doing estrogen tablets 2mg twice a day as well as a pump of androgel. This clinic is more generous with freezing, so they tested and froze a few other blasts as well, which the other clinic would have thrown out. Create an account or log in to participate. An FSH drop-down protocol is used to Group Black's collective includes Essence, The Shade Room and Naturally Curly. I have had 4 failed ivf cycles on the short antagonist protocol which all failed, 3 out of the 4 cycles I had 1 average embryo which resulted in chemical pregnancies and 1 cycle I had nothing to. But there is one more protocol to consider: a flare cycle. In my opinion, it's good to be at a place that uses it a lot. To bridge that gap, doctors prescribe drugs that woman take at the start of a cycle to instigate growth of ovarian follicles that contain eggs. Thus, for those most concerned with OHSS (like women with PCOS or high AFC or AMH), this can be an inferior option. Join Tomato Lovers & Participate in the Ukrainian Tribute Growout! Im over 40 and did estrogen priming for a bunch of cycles and a Lupron stop. Some people prefer the term Diminished Ovarian Reserve or Low Egg Reserve for patients who meet this criteria, as the ovarian response to medications for this group is not always necessarily poor, but rather is simply expected to be lower at their given baseline. Estrogen Priming Protocol: In some women who respond poorly to the short protocol (e.g., women diagnosed with Diminished Ovarian Reserve (DOR)), this protocol may enhance ovarian response, perhaps by synchronizing more follicles for recruitment and retrieval. - Baseline u/s and b/w. I am curious what anyone's experience has been with EPP. 5-7 oz Orange, mid season). I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. I sounds like a good plan since the first protocol didn't work out so great. RE put me on Estrogen priming protocol, and I am on Lupron and Cetrotide as well.On Friday, (cycle day 6) the newer nurse thought she saw 11 follicles.. ranging from 5mm to 9mm.. now, Cycle day 9, the other nurse, who has been there forever, saw only 5 and she had a hard time locating my other ovary. Though I had 4 or 5 follicles to begin with, only ended up with one. The combination and duration of drugs to stimulate, suppress, and incite ovulation taken together comprise a protocol. The answer lies in the drug the protocol uses to trigger the eggs to mature so that they can be retrieved. Below is an oversimplified way to visualize this. Anyhoo, I am just curious whose done this and what the difference was in terms of their egg numbers and quality.especially if anyone used it for quality. They suppress leading up to your cycle so that when you start the meds you get a group of follicles to grow together. I understand the idea for the patch is to help time the growth of follicles vs. increase the number? By and large there are two easy ways to think about protocols: how much gonadotropin (the drug that prompts follicles to grow) gets used, and what other drugs get used alongside the gonadotropin which is typically what defines a given protocol strategy. Anyhow, do you know how what they wanted the priming to do? The first question is naturally, which protocol is more likely to deliver a baby, and when investigators looked at the two most popular strategies, Long Agonist and Antagonist, it became clear both were equally effective in the general IVF population. Now this is a guesstimated number. So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). 2 expanded blasts on Day 6 were not biospied. As we discussed there are drugs that stimulate follicles to grow, suppress the follicles ability to release their eggs, and then help catalyze the follicles to mature their eggs so they can be retrieved. Are you wanting to learn more about the IVF process? This educational content is not medical or diagnostic advice. xx, Oww Hun, please dont worry about me, look after yourself, here if you need a listening ear xxx. There are a number of drugs that can be tacked onto the beginning of a cycle that may increase the odds of success. The data supporting the use of growth hormone in poor responders leading up to gonadotropin use is more convincing. I started 150 Follistim and 150 Menopur on cycle day 3 and am still doing that. After my period started, my doctor kept me on the patches for five more days. Has anyone else had this, Hi peeps. I have AMH of 0.1 or something like that. You currently have javascript disabled. 1) focus on the quality (not quantity) of eggs. We use data about you for a number of purposes explained in the links below. I am also preparing to do estrogen priming again. I am about to embark on my IVF#6 cycle (1st time at CCRM)- I've always done OCP/BCP before my IVF stim cycle(antagonist) and have produced between 15-19 eggs each time. The meds alone cost $5,400. Terms of Use - :) worked well for me. My second included BCP before stimulating and I didnt stimulate well. BFP October 22!!!! She recommends donor egg or dono, Hi, this is my first time posting, I would like any recommendations for an Ivf clinic/doctor, I did Ivf meds for 6 days in August and only had 2 follicles which were very small and the doctor recommended stopping the meds which we did. Before starting the pills, we need to wait until you are in the correct stage of your menstrual cycle (the luteal phase). (51.2% vs 25%; p = 0.047) were noted. Any info welcomed!! I am 40 and have a low ovarian reserve. Does anyone have experience with this? DOR does suck, but you can still be successful! Just not sure what type of protocol would be best. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. Several functions may not work. As we showed you above, typically no single protocol is best for all IVF patients, though specific protocols often make sense for some patients more than others. On the other hand, the Long Agonist protocol cant use Lupron as the trigger because it already deploys Lupron elsewhere. Good luck & stay positive!! Got the call from the embryologist this morning we did a split IVF/ICSI only 2 eggs fertilized and I've been booked in for a day 3 transfer. I then did 450 gonal-F and 150 menopur for 12 or 13 days, using ganirelix as well. unfortunately, it was just an age issue, which i knew all along, but i had to try. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization This helps to improve the outcome of the IVF cycle in patients who respond poorly to traditional IVF protocols. Went to retrieval anyway, did ICSI, but it didn't fertilize. I also did ganirelix during this time. I did estrogen and testosterone priming on my second ivf because I was oversuppressed during my first cycle. my RE is going back to the drawing board for my final IVF. This is the most commonly used protocol whose primary features are a shorter duration of injections and a far lower rate of OHSS, thanks to the ability to use Lupron as a trigger. IVF#4 November 2009 - one embryo survived to day 3 transfer - BFN Fortunately, there are a few steps you can take to prevent and. We ended up refinancing our home and getting help from family. They want to try the Estrogen Priming protocol with estrace and prometrium for almost 4 weeks before the stim cycle. Thus, the negative impact of taking a lot of gonadotropin may be minimized in a frozen transfer. My body seemed to appreciate the extra estrogen. It would be great if it cleared up my skin because my skin has been terrible since my retrieval/chemical a few weeks ago! I cannot say if it will be a success yet, as I am currently doing the EPP protocol. A third option, the Flare protocol is used less often and only in very specific patient types (often poor responders). The hypothesis is that if we treat patients prior to starting their IVF cycle with estrogens ( the estrogen priming protocol) or androgens ( such as DHEA) , they will produce more eggs because more follicles will be recruited when we start the superovulation . Yea, sometimes the smallest of tweaks can make such a big difference. As you can see below, amongst women with PCOS, the Antagonist protocol drives comparable success rates but with far lower risk of hyperstimulation. Most experts believe these women just dont seem to respond to increased doses and so above a pretty low threshold of gonadotropin, success rates dont seem to budge much. Male factor, probably DOR and I am a poor responder to IVF drugs MENTS: This time around I did estrogen priming and the results of my day 5 ultrasound were disappointing (8 follicles, with an E2 level of 98.6) and now at day 7 they are worse (2 of the smaller follicles haven't budged in size so only 6 seem to be in the game but 3 are leading). During the first two cycles I was on F, HelloHave been reading the boards, but have never posted. 1997-2023 BabyCenter, LLC, a Ziff Davis company. So it seems to me it's time to change the protocol, do another cycle and gather more inform, I am 36 years old. 9 Over the next several days you will have ultrasound and blood tests periodically and given instructions on the dosage of FSH to take Usually first I also did ganirelix during this time. 10 retrieved, 6 mature, 6 fertilized (half with ICSI), transferred two 8-cell embryos on day three (both with moderate fragmentation, graded B and C-), the four remaining arrested by day 5. I'm 40, doing IVFdue to age and a mc at 10 weeks due to Trisomy18. I am praying this makes a huge difference. You are posting as a Guest without being logged in. Thanks for sharing. All rights reserved. Find other members in this community to connect with. I might have ovulated rather than had empty follicles. Did not cover diagnostics like doppler test (40 copay but insurance might have covered this), communicable testing ($400 per person), and specialty meds . Please enable JavaScript in your browser to load the challenge. I am on my first round of IVF (hopefully last!). Ramped up to cycle on BCP for two weeks and Lupron 10 units 2x/day on stims. Dwarf Mr Snow, Fred's Tie Dye, Saucy Mary, Sweet Scarlet, Kangaroo Paw Green, Idaho Gem and Banana Toes are just a few of the varieties one gardener is growing in a 4x8 bed of "bulletproof" tomatoes. This was my worst cycle ever only yielding 2 retrieved follicles that did not fertilize. I am scheduled to take estrace 7 days after ovulation coming up (the cycle before) presumably for about 7 days until next cycle Not sure why you would do prometrium before you cycle? Hottest Topics -- Last 30 Days Again, gonadotropin is the injectable hormone that prompts a higher number of follicles, and thus eggs, to grow at any one time. Did one cycle of IVf with 450 of gonal F and then cetrotide and ovidrel. I hope you get to eat those words, I really do!!! However, sometimes when sliced open, white rings can appear in the flesh, a disorder known as "internal white tissue." By clicking sign up, you agree to receive emails from FertilitySmarts and agree to our Terms of Use and Privacy Policy. After seven long years consumed by infertility I am finally moving forward, wishing my son was with me, but grateful for the two children I have here with me. HiI'm new. You are posting as a Guest without being logged in. Similarly, when an investigator named Revelli decided to swap out a few days of gonadotropin for clomid in this poor responder population in Italy (and thereafter resumed gonadotropin at low levels), he saw similar rates of success to more conventional levels of gonadotropin use. The #1 app for tracking pregnancy and baby growth. Note that once you confirm, this action cannot be undone. IVF #5 was EPP and HGH. Our mission is to be a trusted partner in helping you understand your reproductive health and to support and empower the choices you make along the way. Please enable JavaScript in your browser to load the challenge. Infertility Support Community in Partnership with RESOLVE. From NE Ohio to North Central Mississippi, everyone has their own ideas and preferences for what they will plant this year. So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). However, the study has two major shortcomings and for that reason most experts arent ready to concede that rates of gonadotropin over 300 IUs per day is harmful. Most of the costs are for the ER visit, tests, and lab work from my night in the hospital and the weeks following. After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. Ultimately, for only a handful of patient types has one protocol shown itself to be superior to the others and we profile those below. A fundamental question is whether protocols using a lower dose of gonadotropins do as well as those using a higher dose of gonadotropins. Below you can see that when investigators gave poor responders 450 IUs or 150 IUs per day, the groups had nearly identical success rates. I need to know if anyone has had a similar experience, but later got pregnant and where did you go. DH: 36 One of the most important steps in the in vitro fertilization is stimulating the ovaries to develop multiple eggs. That sounds nuts to me, but my doctor said that it is normal. FertilitySmarts Inc. - Today, most IVF cycles use a frozen transfer whereby embryos are frozen and transferred at least a month after the retrieval. The last cycle, I was able to produce 10 eggs but only 2 made it to transfer. Estrogen is administered during the luteal phase of the previous menstrual cycle to "prime" the FSH receptors which enhances the response to FSH. I credit the advice I received on this forum both from members and from experts, my infertility doctor and my push for the estrogen priming protocol for the family that I have today. It is used on lowish amh patients and those who respond poorly to drugs which affect their lining. There seems to be two schools of thought: Estrogen Priming protocol does not have birth control pills. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. IUI pregnancy rates can only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15%. Interesting that they are only putting you on it for 7 days.. In the case of the fresh transfers, you can clearly see a similar effect to what investigators found above: success rates drop with more drug. Please re-enable javascript to access full functionality. I think if I hadn't EPP, I wouldn't have had to stim so high.
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